03/23/2022
Anapharm Bioanalytics acquires a new high sensitivity equipment: SCIEX Triple Quad 6500+ system
Anapharm Bioanalytics’ small molecule division continues to expand its capabilities with the acquisition of a new LC-MS/MS equipment tailored for method development and validation of high sensitivity assays. The new instrument increases our capabilities for peptide chemistry as well as for orally inhaled drugs such as for example Glycopyrronium; Indacaterol, Fluticasone, Salmeterol, Budesonide, Tiotropium, etc. in biological fluids.
The Triple Quad 6500+ system features multi-component IonDrive Technology including the IonDrive High Energy Detector+ that delivers revolutionary sensitivity, speed, and performance for the most challenging methods.
MORE NEWS
Webinar #1: Navigating Bioanalytical Challenges: from Small Molecules to Complex Peptides
In this 30-minute on-demand webinar, discover practical strategies to troubleshoot common analytical challenges, from small molecules to complex peptides, illustrated with real case studies from our laboratory.
Anti-PEG Antibodies: How Advanced Immunogenicity Testing Overcomes Detection Challenges
Detecting anti-PEG antibodies in clinical immunogenicity testing of PEGylated therapeutics presents unique bioanalytical challenges: from PEG’s repetitive structure causing low signal-to-noise ratios in standard assay formats, to selecting appropriate positive controls and distinguishing anti-drug from anti-PEG antibodies. This blog describes how the bioanalytical team at Anapharm Bioanalytics addressed these challenges during the development and validation of an immunogenicity assay using the Affinity Capture Elution–AGL (ACE-AGL) MSD immunoassay format.
Protein Digestion for LC-MS Bioanalysis: Comparing Standard and Kit-Based Methods
Quantitative bioanalysis of therapeutic proteins via liquid chromatography–mass spectrometry (LC-MS) typically relies on the analysis of surrogate peptides rather than intact proteins. Selecting the right digestion method impacts sensitivity, reproducibility, and cost. This blog compares three approaches tested in-house at Anapharm: standard trypsin digestion, the use of a kit with a thermostable immobilized trypsin, and a kit with ready-to-use reagents.